Innovative Medical Solutions for COVID-19

Pulmonem Inc. was founded to demonstrate the effectiveness and safety of a reformulated and patented version of Dapsone, a generic drug, to arrest the development of inflammation caused by COVID-19 and help prevent hospitalization of those who become infected. Pulmonem has established manufacturing partnerships that will allow the Company to quickly bring this treatment to market soon after successful completion of clinical trials.

Pulmonem is also pursuing solutions for the pediatric market, as well as alternative delivery systems, such as nasal sprays and liquids.


Latest News

October 12, 2020 – Acadie Nouvelle

Une entreprise de Dieppe espère développer un traitement contre la COVID-19

October 10, 2020 – Journal de Montréal

L’étude sur la colchicine traîne de la patte et peine toujours à trouver ses cobayes

October 9, 2020 – Radio-Canada

16:39 | Une start-up de Dieppe développe un traitement contre la COVID

The Innovation

Pulmonem is developing and testing a therapy to treat COVID-19 with a newly patented oral medication to arrest the development of inflammation caused by COVID-19 infection, preventing the excessive immune reaction that is the most frequent cause of worsening symptoms and complications requiring hospitalization.

COVID-19 has already affected more than 24 million people around the world and severely disrupted the global economy. By neutralizing the aspect of COVID-19 that causes the gravest complications and fatalities, Pulmonem’s medication could allow for a return to “normal life”, while the world awaits a vaccine.

The therapy developed by Pulmonem is unique in that it is a reformulation of Dapsone, a safe and affordable generic anti-inflammatory drug that has been around for decades, used to treat malaria, lupus, HIV and other inflammatory infections. Because the new medication is a reformulation of an existing drug for a new indication, this therapy could be available on a much-accelerated timeline compared to others in development. 

Pulmonem has manufacturing partnership agreements in place and is ready to start producing its new medication for the treatment of COVID-19 quickly and in large quantities. Manufacturing is set to take place in New Brunswick and in the U.S. for immediate worldwide distribution upon the successful completion of the trial and regulatory approvals.

Pulmonem’s medication could be ready to be administered to Canadians before the end of 2020. 


DAP-CORONA Clinical Trial

Pulmonem will be the first company to investigate the use of a reformulated and patented version of Dapsone as a treatment for COVID-19. The Company will test an early treatment approach to arresting COVID-19 complications among non-hospitalized, confirmed cases during its DAP-CORONA Phase 3 Clinical Trial.

The Phase 3 Clinical Trial is sponsored by the Research Institute of the McGill University Health Centre (RI-MUHC).

DAP-CORONA is a randomized, triple-blind, placebo-controlled, parallel, multicentre trial to evaluate the efficacy and safety of the reformulated and patented version of Dapsone in older adults (70+ years of age) and/or in adult patients (40+ years of age) with at least one high-risk comorbidity, with confirmed COVID-19 infection.

The trial will comprise a total of 2,100 infected patients diagnosed with COVID-19, non-hospitalized at the time of enrolment and meeting all inclusion and no exclusion criteria. They will be randomized to receive either reformulated and patented version of Dapsone tablets or placebo tablets for 21 days and will be followed up for 30 days after termination of treatment.


The Advantages of Our Solution

  • We believe that our therapy will alleviate and may even prevent the pulmonary inflammatory phase of COVID-19, helping prevent the hospitalization of those who become infected.
  • The generic drug we are testing has been successfully used as an anti-inflammatory and has been used to treat other infectious diseases, including malaria, lupus, HIV and pneumocystis jirovecii pneumonia.

Our Solution:

  • is based on a generic and thus affordable.
  • is efficiently absorbed (70% to 80%) via the gastrointestinal tract and is therefore suitable for outpatient settings.
  • reaches peak serum concentration in 2 to 6 hours and has a half-life of 20 to 30 hours.
  • is well distributed to the fluid of the alveolar spaces in the lung.
  • has well-documented metabolic, pharmacokinetic and toxicological profiles.

Management Team

Houfar Sekhavat, MD

Founder, President and CEO
Ophthalmologist, serial entrepreneur and innovator. Founder of Triple Hair Inc. (hair growth therapies) and Hexiris Pharma Inc. (treatment of glaucoma).

Jean-Philippe Gravel, MBA 

Co-Founder and Chief Operating Officer
Over 15 years of experience in management and business development, mainly with medical, pharmaceutical and natural health product companies. President and CEO of Triple Hair Inc.

Bruno Battistini, BSc, MSc, PhD-Pharmacology

Co-Founder, Chief Clinical and Government Affairs Officer
Accomplished health care researcher, former professor of medicine, entrepreneur, senior executive and administrator whose background in pharmacology has resulted in a broad range of experience working with universities, government agencies and health foundations.

Denis Albert, CPA, CA

Co-Founder
Managing partner at Boudreau Albert Savoie & Associates, in charge of operations, strategic direction and client relationships, with over 21 years of experience in accounting, tax planning and business-related matters, including tax and financial restructuring, financing, business sales and acquisitions. 

Erika Tremblay-Gagnon, CPA CA, M.Sc.

Chief Financial Officer
Over 14 years of financial executive experience, mainly as VP, Corporate Finance with TSX-listed Stingray Group and Senior Manager, Audit and Certification at PricewaterhouseCoopers. 

Satish Asotra, Ph.D., MBA

Chief Manufacturing and Regulatory Officer
Senior executive and strategic leader with a proven track record of driving pharmaceutical development, innovation and process improvement with 25 years of experience, including more than 12 years in topical and dermatological product development, with Avicanna, AHI, Accucaps, Odan Laboratories and Taro Pharmaceuticals. 

Attila Hajdu, M.Sc., MBA

Vice President, Business Development
Accomplished leader with over 20 years of experience years in the global pharmaceutical and biotechnology industry, mainly in business development, sales, marketing, finance and medical affairs with GlaxoSmithKline, Astellas, Sirona Biochem, and Stelvio Therapeutics. 

Avraham Yacobi, Ph.D., M.Pharm.

Principal Scientific Advisor
Expert consultant with over 35 years of experience in pharmaceutical R&D and regulatory affairs. Previously served as President of R&D at Taro Pharmaceuticals USA for 16 years, and as Senior VP and Officer at Taro Pharmaceutical Industries. Currently President of DOLE Pharma, LLC and Founder and Scientific Advisor to BluPax Pharma. 

RI-MUHC Team

Dr. Jean Bourbeau

Principal Investigator

Professor (Medicine), McGill University; Respirologist, MUHC; GSK-CIHR Research Chair and Director, Centre for Innovative Medicine, RI-MUHC.

Dr. Bryan Ross

Quebec Site Investigator

Assistant Professor (Medicine), Respirologist, MUHC, McGill University.

Dr. Sharmistha Biswas

Study Investigator 

PhD (c) Experimental Medicine-Epidemiology, RI-MUHC, McGill University.

Dr. Andrea Benedetti

Study Investigator 

Associate Professor (Medicine; Epidemiology & Biostatistics) McGill University; Scientist, RI-MUHC.

Other Sites in Canada

Dr. Kenneth Chapman

Ontario Site Investigator

Professor (Medicine), University of Toronto; President, Inspiration Research Ltd. Toronto.

Full Bio

Dr. Matthew B. Stanbrook

Ontario Site Sub-Investigator 

Associate Professor (Medicine), University of Toronto.

Full Bio

Dr. Joshua Wald

Ontario Site Sub-Investigator 

Assistant Professor (Medicine), McMaster University.

Full Bio

US Sites

Dr. Gerard Criner 

Co-Principal Investigator, Pennsylvania Site 

Professor and Chair (Thoracic Medicine and Surgery), Temple University; Director, Temple Lung Center.

Full Bio

Dr. Omar Gonzalez

Arizona Site Investigator 

Director (Infection Control), Dignity Health St. Joseph’s Hospital and Medical Center. 

Full Bio

Dr. Richard Sue 

Arizona Site Sub-Investigator 

Respirologist and Intensivist, Dignity Health St. Joseph’s Hospital and Medical Center.

Full Bio

Dr. William W Stringer

California Site Investigator 

Professor (Medicine), Geffen School of Medicine, UCLA.

Full Bio

Dr. Janine Vintch

California Site Sub-Investigator 

Professor (Medicine), David Geffen School of Medicine, UCLA.

Full Bio

Dr. Fortune Alabi 

Central Florida Site Investigator 

Respirologist and Intensivist, Florida Lung, Asthma & Sleep Specialists.

Full Bio

Dr. Shirin Shafazand 

Miami Site Investigator 

Professor (Medicine), Miller School of Medicine, University of Miami.

Full Bio

Dr. Frank Sciurba  

Pittsburgh Site Investigator

Professor (Medicine), University of Pittsburgh School of Medicine.

Full Bio

Dr. Alison Morris 

Pittsburgh Site Sub-Investigator 

Professor (Medicine), University of Pittsburgh School of Medicine.

Full Bio


Looking to Invest?

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Pulmonem Inc.
855, Dieppe Blvd
Dieppe, NB  E1A 7R8
CANADA

Media Enquiries
Keelan Green
613-220-2016
green@prospectus.ca